郭建丽 高级工程师
邮箱:guojianli19880728@163.com
政治面貌:中共党员
教育经历:
2014.9~2019.11:大连理工大学,生物化工,工学博士
2011.9~2014.7:大连海洋大学,海洋生物学,理学硕士
2011.3~2014.8 :国家海洋环境监测中心,海洋微生物生态学(联合培养)
2007.9~2011.7:大连海洋大学,生物技术,理学学士
研究方向:
环境微生物的检测;天然活性成分的分离、纯化;协同抗癌药物的筛选;药物的药效学和药理学研究;功能食品的开发。
已发表的文章:
(1) Jianli Guo, Qin Tang, Qingling Wang, Wenhui Sun, Zhongji Pu, Jingyun Wang, Yongming Bao. Pifithrin-α Enhancing Anticancer Effect of Topotecan on p53-expressing Cancer Cells, European Journal of Pharmaceutical Sciences, 2019, 128:61-72.
(2) Jianli Guo, Qingling Wang, Yue Zhang, Wenhui Sun, Shuangzhe Zhang, Yachen Li, Jingyun Wang, Yongming Bao. Functional Daidzein Enhances the Anticancer Effect of Topotecan and Reverses BCRP-mediated Drug Resistance in Breast Cancer, Pharmacological Research, 2019, 147:104387.
(3) Qin Tang, Fangling Ji, Jianli Guo, Jingyun Wang, Yachen Li, Yongming Bao. Directional Modification of Chrysin for Exerting Apoptosis and Enhancing Significantly Anti-cancer Effects of 10-hydroxy Camptothecin, Biomedicine &Pharmacotherapy, 2016, 82:693-703.
(4) Qin Tang, Fanglin Ji, Wenhui Sun, Jingyun Wang, Jianli Guo, Lianying Guo, Yachen Li, Yongming Bao. Combination of Baicalein and 10-hydroxy Camptothecin Exerts Remarkable Synergetic Anti-cancer Effects, Phytomedicine, 2016, 23:1778-1786.
(5) Bo Jiang, Shangli Zheng, Lijia An, Jianli Guo, Tetsuya Asakawa. Changes in Striatal Dopamine Transporter and Tyrosine Hydroxylase Expression Associated with Fatigue and Their Reversal by Blueberry Juice, Journal of Berry Research, 2019,1-12.
(6) Qingling Wang, Fangling Ji, Jianli Guo, Yuepeng Wang, Yanyan Li, Jingyun Wang, Lijia An, Yongming Bao. LotS/LotR/Clp, a Novel Signal Pathway Responding to Temperature, Modulating Protease Expression via C-di-GMP Mediated Manner in Stenotrophomonas Maltophilia FF11. Microbiological Research 2018, 214: 60-73.
(7) Nora Elfeky, Mostafa Elmahmoudy, Yue Zhang, Jianli Guo, Yongming Bao. Lipid and Carotenoid Production by Rhodotorula Glutinis with a Combined Cultivation Mode of Nitrogen, Sulfur, and Aluminium Stress. Applied sciences 2019, 9(12):2444.
(8) Shuangzhe Zhang, Miao Li, Wenxi Xia, Jiangli Fan, Jingyun Wang, Yueqing Li, Yachen Li, Haibo Wang, Chengyong Dong, Dandan Ma, Jianli Guo, Xiaojun Peng. Imaging and Inhibiting: A Dual Function Molecular Flare for Cancer cells, Analytical Chemistry,2019,91(21):13501-13507.
(9) Wenhui Sun, Bo Jiang, Yue Zhang, Jianli Guo, Dongying Zhao, Zhongji Pu, Yongming Bao. Enabling the Biosynthesis of Malic Acid in Lactococcus lactis by Establishing the Reductive TCA Pathway and Promoter Engineering, Biochemical Engineering Journal ,2020,161:107645.
(10) 郭建丽, 樊景凤, 付慧, 明红霞, 袁秀堂, 王斌. 双台子河口沉积物中细菌多样性分析[J]. 微生物学通报, 2013, 40(9):1550-1559.
(11) 郭建丽, 陈佳莹, 明红霞, 袁秀堂,樊景凤. 文蛤对环境中 TN、 TP 的影响及其指示微生物活性指标的确定[J]. 海洋环境科学, 2015, 34(6):909-915.
(12) 郭建丽, 王玥, 李江宇, 明红霞, 苏洁, 关道明, 王斌, 樊景凤. 大连重要海水增养殖区粪便污染指示菌和弧菌的时空分布[J]. 海洋环境科学, 2017, 36(6):813-819.
(13) 张春鑫, 石峰, 明红霞, 关道明, 赵顺, 郭建丽, 李洪波, 樊景凤. 渤黄海夏季表层海水中好氧不产氧光合细菌多样性分析[J]. 海洋环境科学, 2015, 34(2):225-233.
(14) 昝帅君, 樊景凤, 明红霞, 郭建丽, 王玥, 常永凯, 郭皓. 辽河口粪便污染指示菌的时空分布特征[J]. 环境科学学报, 2015, 35(11):3587-3594.
申请专利:
郭建丽,张岳,孙世博,闫志刚,贺高红,张艳丽,郭爽。一种提高人源II型硫氧还蛋白还原酶稳定性的方法,专利申请号为:202110766202.7
参译书籍:
《海洋与健康:海洋环境中的病原体》,北京,海洋出版社,2014,书号: ISBN978-7-5027。
参加项目:
2011.9~2012.12:参加海洋公益性行业科研专项“典型海湾生境与重要经济生物资源修复技术集成及示范”, 项目编号:20080569
2012.7~2014.5:参加海洋公益性行业科研专项项目子任务“重要海域致病性细菌基因芯片检测技术研究开发与示范” ,子项目编号: 201105007-3。
2013.12~2014.3:参加“人类肠病毒在海水中的分布及空间复杂性维持机制”项目,项目编号: 4140060628
2020.9~2022.6:主持辽宁省化学助剂合成与分离省市共建重点实验室开放课题“线粒体硒蛋白稳定剂的开发与应用”,项目编号:ZJKF2004。